Neonatal maternal deprivation promotes Nippostrongylus brasiliensis infection in adult rats
نویسندگان
چکیده
منابع مشابه
Mechanism of fat malabsorption in rats infected with Nippostrongylus brasiliensis.
Long-chain fatty acid absorption in rats with a jejunal lesion similar to that which is found in adult coeliac disease has been studied. Neither changes in the solubility of the fatty acid in the intestinal lumen nor histological abnormalities of the villous epithelium accounted for the malabsorptive state. Evidence was obtained from studies in vivo of a disturbance in the intramucosal esterifi...
متن کاملIL-4Rα-Associated Antigen Processing by B Cells Promotes Immunity in Nippostrongylus brasiliensis Infection
In this study, B cell function in protective T(H)2 immunity against N. brasiliensis infection was investigated. Protection against secondary infection depended on IL-4Rα and IL-13; but not IL-4. Protection did not associate with parasite specific antibody responses. Re-infection of B cell-specific IL-4Rα⁻/⁻ mice resulted in increased worm burdens compared to control mice, despite their equivale...
متن کاملSecondary infection of Nippostrongylus brasiliensis in lactating rats is sensitive to dietary protein content.
Lactating mammals usually exhibit a breakdown of immunity to parasites, i.e. they have larger worm burdens than their non-lactating counterparts. Here, we tested the hypothesis that a secondary infection with Nippostrongylus brasiliensis in lactating rats is sensitive to dietary protein content. We also tested whether this infection affects host food intake. Rats either remained uninfected thro...
متن کاملBreakdown of immunity to Nippostrongylus brasiliensis in lactating rats.
The nutritional basis of breakdown of immunity to parasites may be addressed in a rodent model. We hypothesized that lactating rats would show a breakdown of immunity to Nippostrongylus brasiliensis, and that this breakdown of immunity would be sensitive to protein supply. Rats were immunized with 1600 infective N. brasiliensis larvae and subsequently mated. During lactation, these rats were of...
متن کاملIntestinal permeability in rats infected by Nippostrongylus brasiliensis.
Passive intestinal permeability has been investigated in rats infected by the nematode, Nippostrongylus brasiliensis, by the simultaneous administration of two probe molecules. Experiments using a closed intestinal loop show that there is a significantly increased absorption of lactulose and decreased absorption of mannitol in rats at the 10th to 11th day of infection. Experiments using serial ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Brain, Behavior, and Immunity
سال: 2006
ISSN: 0889-1591
DOI: 10.1016/j.bbi.2005.07.003